Development of a Novel Polyamide-Based Agent to Inhibit EVI1 Function
نویسندگان
چکیده
منابع مشابه
Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide.
The zinc finger protein EVI1 is causally associated with acute myeloid leukemogenesis, and inhibition of its function with a small molecule therapeutic may provide effective therapy for EVI1-expressing leukemias. In this paper we describe the development of a pyrrole-imidazole polyamide to specifically block EVI1 binding to DNA. We first identify essential domains for leukemogenesis through str...
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ژورنال
عنوان ژورنال: Blood
سال: 2008
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v112.11.2660.2660